Skip to main content

A matter of months after possession of psilocybin mushrooms was decriminalized in Denver, Colorado and Oakland, California, another major step has been made in their road to public accessibility. The U.S. Food and Drug Administration (FDA) has given the entheogenic a "Breakthrough Treatment" designation, opening doors for further research into the substance's benefits for sufferers of major depressive disorder (MDD), better known simply as depression.

The designation acknowledges the strong preliminary evidence showing psilocybin's treatment potential for depression and offers "intensive guidance" from the FDA. It's the second time in just over a year that psilocybin was granted such a status; the last time was in October of 2018 after COMPASS Pathways determined the compound to aid those suffering from treatment-resistant depression. 

Nonprofit research organization Usona Institute recently commenced a Phase 2 clinical trial in which 80 people will take a single, one-time dose of psilocybin orally. The purpose of the trial will be to determine how effectively the compound treats depression. 

Researchers have been quick to point out that those with depression should not self-medicate with psilocybin as it is easy to confuse mushroom strains and difficult to determine proper dosage. Even in decriminalized cities, psilocybin mushrooms are still technically illegal by state and federal law throughout the U.S. 

Recommended Articles

Nicky Romero Playlist Picks: Nicky Romero, Mura Masa, Crankdat and More [11/26/21]

New major releases include tracks from Alan Walker, FAULHABER, NIGHTMRE and more.

Adventure Club at Havana Nightclub in The Grand Oasis at Pollen Presents Electric Zoo Cancun

Adventure Club On New Album, NFTs and the Future of Melodic Dubstep

"It’s important to give the power back to musicians as opposed to having a middleman kind of control everything."

H/T: Popular Science


kacey musgraves

Kacey Musgraves Lists Daft Punk, Magic Mushrooms as Influences of Upcoming Album

The six-time Grammy Award winner recently spilled the tea on the influences behind her forthcoming feature-length album, due later this year.

Psilocybin Mushrooms

Mind Medicine and Other Psychedelics Companies Looking to Go Public in 2020

Amid psilocybin mushrooms' decriminalization in more and more U.S. cities, psychedelics are going corporate.


Death of i_o Revealed to Be a Result of Natural Causes

The Los Angeles County Department of Medical Examiner-Coroner's report listed a thyroid disorder as i_o's cause of death.

Music Festival Audience

10 Symptoms of Post-Music Festival Depression

Here's How You Know You're Suffering From Post-Music Festival Depression

Porter Robinson

Porter Robinson Opens Up About Overcoming Depression to Produce "Nurture"

"The album came after a real kind of emotional and creative low point for me, where I just was genuinely feeling like I was not capable of making music anymore."


Musicians are Three Times More Likely to be Depressed, Study Finds

MusicTank and the University of Westminister found that 68.5% of respondents stated they experienced depression.

infected mushroom

Celebrating 25 Years of Psytrance: Infected Mushroom Talk Virtual Reality, NFT's, and New Album

"We haven’t done an album that is as diverse since 2009’s Legend of the Black Shawarma. This is as much of an Infected Mushroom album as it gets."