Skip to main content

A matter of months after possession of psilocybin mushrooms was decriminalized in Denver, Colorado and Oakland, California, another major step has been made in their road to public accessibility. The U.S. Food and Drug Administration (FDA) has given the entheogenic a "Breakthrough Treatment" designation, opening doors for further research into the substance's benefits for sufferers of major depressive disorder (MDD), better known simply as depression.

The designation acknowledges the strong preliminary evidence showing psilocybin's treatment potential for depression and offers "intensive guidance" from the FDA. It's the second time in just over a year that psilocybin was granted such a status; the last time was in October of 2018 after COMPASS Pathways determined the compound to aid those suffering from treatment-resistant depression. 

Nonprofit research organization Usona Institute recently commenced a Phase 2 clinical trial in which 80 people will take a single, one-time dose of psilocybin orally. The purpose of the trial will be to determine how effectively the compound treats depression. 

Researchers have been quick to point out that those with depression should not self-medicate with psilocybin as it is easy to confuse mushroom strains and difficult to determine proper dosage. Even in decriminalized cities, psilocybin mushrooms are still technically illegal by state and federal law throughout the U.S. 

Scroll to Continue

Recommended Articles


Zedd Reveals One-Time-Only "Clarity" Ten Year Anniversary Performance in San Francisco

At the special event, Zedd will play every track from his 2012 debut album.


Set Times and Special GRiZ Performance Announced for Movement 2022

The Detroit festival will feature performances from Jeff Mills, The Martinez Brothers, Carl Craig, Maya Jane Coles, Flying Lotus, Chris Lake, and more.

H/T: Popular Science


kacey musgraves

Kacey Musgraves Lists Daft Punk, Magic Mushrooms as Influences of Upcoming Album

The six-time Grammy Award winner recently spilled the tea on the influences behind her forthcoming feature-length album, due later this year.

Psilocybin Mushrooms

Mind Medicine and Other Psychedelics Companies Looking to Go Public in 2020

Amid psilocybin mushrooms' decriminalization in more and more U.S. cities, psychedelics are going corporate.


This Rave Promoter Is Also a Rabbi Who Curates Magic Mushroom Retreats for His Congregation

Ben Gorelick is bringing a newfangled approach to the idea of organized religion.

Alesso and Katy Perry

Alesso Makes Saturday Night Live Debut Alongside Katy Perry to Perform "When I'm Gone": Watch

The performance featured psychedelic visuals and dancers dressed in phallic mushroom costumes.


Death of i_o Revealed to Be a Result of Natural Causes

The Los Angeles County Department of Medical Examiner-Coroner's report listed a thyroid disorder as i_o's cause of death.

Music Festival Audience

10 Symptoms of Post-Music Festival Depression

Here's How You Know You're Suffering From Post-Music Festival Depression

Porter Robinson

Porter Robinson Opens Up About Overcoming Depression to Produce "Nurture"

"The album came after a real kind of emotional and creative low point for me, where I just was genuinely feeling like I was not capable of making music anymore."