The trio also shared the official music video for their new single, titled "You."
The news arrives shortly after Marshmello's declaration that his fourth studio album is finished.
The new collaborative single was released over the weekend on the late hip-hop star's 22nd birthday.
FKA twigs also enlisted Benny Blanco, Nicolas Jaar and Noah Goldstein.
Calvin Harris hasn't contributed vocals to a track since 2016.