Defected will promote the work of industry pros who have found themselves unemployed due to the pandemic.
For her latest remix, Honey Dijon took on Calvin Harris' Defected Records debut.
Purple Disco Machine, Ferreck Dawn, Low Steppa, and more will also appear.
Defected will sponsor five students per term at Bridges Academy in Langa, Cape Town.
He is due out with a single titled "Live Without Your Love" next month.
Harris' acid-house alias will join Claptone, Roger Sanchez, and more for Defected's virtual festival.
Guetta is back to his underground house roots